EXPERIMENTAL DEVELOPMENT AND MOLECULAR DOCKING: NANOSTRUCTURED LIPID CARRIERS (NLCs) OF COENZYME Q10 USING STEARIC ACID AND DIFFERENT LIQUID LIPIDS AS LIPID MATRIX

Objective: To develop coenzyme Q10 (co-Q10) nanostructured lipid carriers (NLCs) using stearic acid (SA) and various liquid lipids with different lipophilicity as well highlights the use of in silico studies for predicting elucidating interaction drug-lipid used carries NLCs, at molecular level.
 Methods: The co-Q10 NLCs were prepared SA solid oleic (OA), isopropyl myristate (IPM), palmitate (IPP) by high shear homogenization method. Firstly, formulas optimized appropriate required HLB (rHLB). characterized particle size, distribution zeta potential, crystallinity behavior, Fourier transform infrared (FT-IR) spectra, morphology, entrapment efficiency (EE), drug loading (DL), pH value. drug-lipids was studied AutoDock Vina program.
 Results: possessed mean polydispersity index (PDI), EE, DL, values 180 to 350 nm,<0.5,<-30 mV, 83 88%, 10 11%, 5.0 5.6, respectively. EE DL increased decreasing binding energy (∆G) silico.
 Conclusion: OA, IPM, IPP developed successfully. Furthermore, study docking is a potential approach development formulation.